Author: aracila

Can we be flexible in exercise recommendations to people with MASLD?

People with metabolic dysfunction-associated fatty liver disease (MASLD) benefit from physical activity. But incorporating regular physical activity into the daily routines of patients with MASLD can be challenging due to time limitations and accessibility issues. These challenges are further compounded by the fatigue associated with MASLD. To support individuals with MASLD in initiating and maintaining physical activity, it is therefore essential to recommend activity patterns that are both effective and personalized to enhance adherence and long-term engagement. So far, it has been unclear if exercising during concentrated time over two days per week, for example, on weekends ("weekend warrior" style) is as effective as spreading it throughout the week. The study from the Global NASH/MASH Council (GNC) published in Liver International found that both weekend warriors and regularly active individuals had lower rates of MASLD, lower risk of heart disease, and lower mortality than those who were inactive. These results suggest that even concentrated bursts of exercise can provide major health benefits for people with MASLD.

Steatotic Liver Disease: Evolving from Static Diagnosis to a Dynamic Spectrum

Members of the Global NASH/MASH Council (GNC) are helping reframe Steatotic Liver Disease as a dynamic and evolving spectrum. In a recently published letter, Drs. Zobair M. Younossi, Shira Zelber-Sagi and Aleksander Krag share their expert insights on the future of this significant liver disease. Their perspective highlights the urgent need for a unified approach to diagnosis, management, and global awareness. Download PDF version

Global NASH/MASH Council (GNC) Meeting at INASL 2025 Annual Conference

The Global NASH/MASH Council (GNC) convened a highly productive meeting during the 33rd Annual Conference of the Indian National Association for the Study of the Liver (INASL), held August 7–10, 2025, in Chandigarh, India. Focusing on the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) in South and Southeast Asia, the 3.5-hour session brought together leading hepatology experts from across the region. Opening remarks were delivered by Professor Ajay Duseja (Secretary General, INASL), Professor Radha K. Dhiman (President, INASL), and Professor Zobair M. Younossi (Chairman, GNC). The meeting highlighted the escalating burden of MASLD/MASH and laid the groundwork for expanded regional and global collaboration. Discussions are expected to foster impactful partnerships to advance research, increase disease awareness, and improve treatment strategies not only within South and Southeast Asia, but also in other regions represented by the GNC. Please follow this link to watch the entire meeting.

Dimer Diabetes 2025, Bodrum, Turkey (October 26-29)

The Global NASH/MASH Council is delighted to collaborate with Dimer Diabetes 2025 which is a scientific meeting in Bodrum, Turkey with exceptional faculty and agenda. For more information about Dimer Diabetes 2025, please use the following link. https://www.dimerdiabetescenter.com/

The Global NASH/MASH and Global Liver Council Meetings During ILC 2025 in Amsterdam

GNC and GLC had another very successful meeting during ILC 2025 with over 70 members participating. The meeting was full of exciting reports related to the projects of different GNC/GLC committees. Additionally, an in-depth 3 hours meeting was dedicated to MASLD/SLD discussing NIT algorithms in clinical practice, awareness challenges, patient perspective about MASLD, preventive hepatology and Burden of Disease/Cost of Inaction for MASLD. These discussions will lead to more projects helping to move the field forward as well as recommendations to policy makers about actions that are needed to deal with MASLD at a global level.

Global Consensus Recommendations for Metabolic Dysfunction-Associated Steatotic Liver Disease and Steatohepatitis, Gastroenterology, April 11, 2025

The Global NASH/MASH Council (GNC) has just published in Gastroenterology (April 11, 2025, In Press) the most comprehensive recommendations about MASLD and MASH. After systematically reviewing 61 guidelines and similar documents (2018-2025) and undertaking an extensive Delphi process, the Global Recommendations for MASLD/MASH provide the most updated clinically relevant information on all aspects of MASLD/MASH including risk stratification, diagnosis, lifestyle management and medical treatment to optimize person-centric care of MASLD/MASH. To see the full abstract, please click https://www.gastrojournal.org/article/S0016-5085(25)00632-8/fulltext Download PDF version

The Global NASH Council Meeting During APASL 2025, Beijing, China March 27, 2025

The Global NASH/MASH Council (GNC) meeting was held during APASL 2025 in Beijing, China. The meeting was co-chaired by Professor Zobair M. Younossi and Professor Jiangao Fan and was attended by over 50 members in person and another 12 via zoom. A number of important topics related to the disease burden, NITs, risk stratification and treatment of MASH in the Asian Pacific region were discussed by the highly respected international members of GNC. Additionally, GNC and its network of global collaborators discussed the ongoing research projects and expressed interest to continue to expand their projects to address Steatotic Liver Disease as one of the most important non-communicable diseases. The members continued their commitment to the Global registries maintained by GNC and the future collaborative projects. Professor Younossi and Professor Fan open the Global NASH/MASH Council-APASL 2025