Global NASH Council & Global Liver Council
33 Active Research Projects
SURVEY PROJECTS
| Project Title and Description | Status | Project Director | |
|---|---|---|---|
| 4 | Pediatric MASLD Knowledge Survey Survey of pediatric hepatologists/gastroenterologists and general pediatricians across the world in managing MASLD. | Actively Enrolling | Jillian Price jillian.price@cldq.org |
| 3 | Africa Sub Committee: survey to determine knowledge and resource needs Survey to determine knowledge and resource needs for managing MASLD in different countries in Africa. | Actively Enrolling | N/A |
| 2 | Hepatitis B & D provider survey Assessment of practice patterns in managing HBV and HDV in different regions of the world. | Enrollment Closed in Analyses | Linda Henry linda.henry@cldq.org |
| 1 | ALD Stigma Survey: patient and provider surveys Assessment of ALD-related stigma issues from both patients and providers (hepatologists, gastroenterologists and others) across all regions of the world. | Actively Enrolling | Fatema Nader fatema.nader@cldq.org |
PROSPECTIVE REGISTRIES
| Project Title and Description | Status | Project Director | |
|---|---|---|---|
| 6 | Collaboration with King Faisal Specialist Hospital & Research Centre Established a strategic collaboration with King Faisal Specialist Hospital & Research Centre, resulting in the submission of multiple joint scientific abstracts and the development of several collaborative research projects focused on MASLD and other metabolic diseases affecting the liver. Through the Global NASH Council (GNC) and the Center for Outcomes Research in Liver Disease (CORLD), we also supported the implementation of the Global Liver Registry within the hospital and other healthcare systems in SA using the REDCap platform integrated into their institutional infrastructure. | Actively Enrolling | Fatema Nader fatema.nader@cldq.org |
| 5 | Global Liver Registry: Prospective enrollment of 5 liver diseases (MASLD/MASH, HCV, HBV, PBC and ALD) across 30 clinical centers around the globe Prospective enrollment of patients with 5 liver diseases (MASLD/MASH, HCV, HBV, PBC and ALD) across 30 clinical centers around the globe to assess clinical characteristics, laboratory data, PROs and long-term outcomes. These patients are enrolled and followed on an annual basis. | Actively Enrolling | Fatema Nader fatema.nader@cldq.org |
CME EDUCATIONAL INITIATIVES
| Project Title and Description | Status | Project Director | |
|---|---|---|---|
| 7 | MASH Alliance Program: 10 regional city series across the US Comprehensive educational program targeted at providers (gastroenterologists, hepatologists, endocrinologists, primary care physicians and their advanced practitioners) to understand the burden of MASLD, risk stratification algorithms and management. These programs are implemented by CLDF. | Active | Fatema Nader fatema.nader@cldq.org |
Global - MASLD Projects
| Project Title and Description | Status | Project Director | |
|---|---|---|---|
| 18 | G-MASLD: MASLD and IBD Assessment of overlap between MASLD and inflammatory bowel disease. | Actively Enrolling | Markos Kalligeros |
| 17 | G-MASLD: Post-Transplant for MASLD/MASH: A Global Study Assessment of characteristics and outcomes of liver transplant for MASLD, MetALD and ALD. The data are being collected retrospectively from transplant sites across the globe. | Actively Enrolling | Linda Henry linda.henry@cldq.org |
| 16 | G-MASLD: MASLD and Viral Hepatitis and HIV Project Assessment of overlap between MASLD and HBV, HCV, HDV and HIV infection. | Actively Enrolling | Margarita Papatheodori |
| 15 | G-MASLD HCC in MASLD Project Assessment of characteristics of HCC in MASLD patients and development of models to predict outcomes. | Actively Enrolling | Leyla deAvila leyla.deavila@cldq.org |
| 14 | G-MASLD Central Pathology Readout and Morphometry Project Centralized reading of scanned liver biopsies by the central pathologist and quantification of collagen in these biopsies using morphometry techniques. | Actively Enrolling | Leyla deAvila leyla.deavila@cldq.org |
| 13 | G-MASLD Burden of MetALD Project Evaluation and comparison of MetALD patients with MASLD based on all available data (clinical, NIT, SNPs and outcomes). | Actively Enrolling | Leyla deAvila leyla.deavila@cldq.org |
| 12 | G-MASLD Lean MASLD Subproject Assessment of characteristics, NITs and outcomes of Lean MASLD from the original Global MASLD cohort. | Actively Enrolling | Leyla deAvila leyla.deavila@cldq.org |
| 11 | Ballooning of Hepatocytes and Long-Term Outcomes in MASLD Subproject Using the G-MASLD project, assessment of the association between specific pathologic features and long-term outcomes in MASLD. | Actively Enrolling | Leyla deAvila leyla.deavila@cldq.org |
| 10 | G-MASLD Outcomes Subproject Determination of predictors of mortality and liver events in a large global cohort of MASLD. | Actively Enrolling | Leyla deAvila leyla.deavila@cldq.org |
| 9 | G-MASLD NIT Performance Subproject Performance of NITs in subpopulations such as diabetic and obese patients and other subgroups. | Actively Enrolling | Leyla deAvila leyla.deavila@cldq.org |
| 8 | Global-MASLD (G-MASLD) Original Project: (liver biopsy) Enrolling patients with biopsy-proven MASLD, with clinical data, laboratory data, NITs and long-term outcomes data from over 40 sites across the globe. | Actively Enrolling | Leyla deAvila leyla.deavila@cldq.org |
BIOMARKER PROJECTS
| Project Title and Description | Status | Project Director | |
|---|---|---|---|
| 19 | PEth Testing in a Cohort of MASLD: Biomarker Project Obtaining PEth results from sites across the globe for MASLD patients. The analysis will provide characteristics of these patients that can separate them from MASLD. | Actively Enrolling | Fatema Nader fatema.nader@cldq.org |
ECONOMIC ANALYSIS & META-ANALYSIS PROJECTS
| Project Title and Description | Status | Project Director | |
|---|---|---|---|
| 23 | Cirrhosis in MASLD Meta-Analysis Meta-analysis of currently available published studies on MASLD-related cirrhosis. | Active | Eliabe Abreu |
| 22 | MASLD-Related HCC Meta-Analysis Meta-analysis of currently available published studies on MASLD-related HCC. | Active | Eliabe Abreu |
| 21 | Economic and Clinical Burden of MASH Among Those with Obesity (US, Germany, Spain, Brazil, Saudi Arabia, Japan, France, Italy & UK) Assessment of clinical and economic burden (prevalence, number of cases, mortality, direct and indirect costs) in individuals with obesity from 9 countries. | Active | James Paik |
| 20 | Economic and Clinical Burden of MASH Among Patients with T2D in 9 Countries Assessment of clinical and economic burden (prevalence, number of cases, mortality, direct and indirect costs) in patients with diabetes from 9 countries. | Active | James Paik |
TRANSPLANTATION
| Project Title and Description | Status | Project Director | |
|---|---|---|---|
| 27 | Transplants for ALD: Liver Transplantation for Alcoholic Hepatitis vs. Cirrhosis — U.S. Registry Data Using US transplant registries to assess characteristics and outcomes of patients receiving liver transplant with alcohol-associated liver disease. | Enrollment Closed in Analyses | Maria Stepanova |
| 26 | UNOS & ELITA Liver Transplantation Databases: Transplants for Hepatic Tumors (Malignant and Benign) Using US and European registries to assess characteristics and outcomes of patients receiving liver transplant for liver tumors. | Enrollment Closed in Analyses | Maria Stepanova |
| 25 | UNOS & ELITA Liver Transplantation Databases: Transplantation for PBC and PSC Using US and European registries to assess characteristics and outcomes of patients receiving liver transplant with PBC and PSC. | Enrollment Closed in Analyses | Maria Stepanova |
| 24 | UNOS & ELITA Liver Transplantation Databases: Hepatitis Delta and Liver Transplantation Using US and European registries to assess characteristics and outcomes of patients receiving liver transplant with HDV. | Enrollment Closed in Analyses | Maria Stepanova |
EPIDEMIOLOGY AND POLICY PROJECTS RELATED TO SLD
| Project Title and Description | Status | Project Director | |
|---|---|---|---|
| 28 | Global Nutrition Project: Validation of a Short UPF Questionnaire; Prospective Cohort on CMRFs & MASLD Validation and utility of a newly developed short version of the UPF questionnaire. | Active | Dana Ivancovsky Wajcman |
| 29 | Global Pathways Linking Alcohol Exposure, Food Systems, and Alcohol-Associated Liver Disease | Active | Dana Ivancovsky Wajcman |
| 30 | Exercise, Activity and MASLD Outcomes: NHANES Project | Active | James Paik |
| 31 | Long-Term Outcomes of MetALD & ALD in Youth (NHANES Restricted Data) | Active | James Paik |
| 32 | Development and Validation of Short Food Frequency Questionnaire | Active | Dana Ivancovsky Wajcman |
| 33 | Omics of MASLD: Analyzing Genomics, Proteomics, and Other Omics Data for 400–500 Patients from the US Using previously collected data on SNPs, gene expression, miRNA, proteomics and metabolomics to better understand different aspects of MASLD. | Enrollment Closed in Analyses | Maria Stepanova |