The prevalence of MASLD/MASH is rising globally, highlighting the urgent need for public health policies that emphasize both prevention and personalized care. MASLD/MASH carries significant clinical, humanistic, and economic burdens worldwide. Primary prevention strategies should prioritize lifestyle interventions guided by a social nutrition agenda, alongside public health initiatives to increase awareness among healthcare practitioners and the general public. For secondary prevention, non-invasive tests (NITs) should be implemented in primary care to enable early disease detection, and approved, accessible therapies targeting MASH should be recommended. Addressing MASLD/MASH through this integrated approach—combining policy reform, public health action, and personalized care—is critical to mitigating its growing impact. An article by the Global NASH/MASH Council (GNC) published today in Liver International, summarizes these important issues and explores all relevant topics in detail.