This month’s cover of the prestigious journal Gastroenterology features a landmark study by the Global NASH/MASH Council (GNC), which developed global consensus recommendations on the burden, risk stratification, and treatment of MASLD/MASH. By systematically reviewing 61 guidance documents worldwide, the study identified 46 areas of discordance that may create uncertainty for clinicians. Through a four-round Delphi process, experts established unified recommendations on screening, risk stratification, and treatment, providing a practical resource to help clinicians identify high-risk patients, optimize management of comorbidities, and select preferred therapies. While these recommendations will need ongoing updates as new therapies and noninvasive tests emerge, the framework also serves to standardize global approaches to MASLD/MASH management and facilitate more consistent research and patient care.