People with metabolic dysfunction-associated fatty liver disease (MASLD) benefit from physical activity. But incorporating regular physical activity into the daily routines of patients with MASLD can be challenging due to time limitations and accessibility issues. These challenges are further compounded by the fatigue associated with MASLD. To support individuals with MASLD in initiating and maintaining physical activity, it is therefore essential to recommend activity patterns that are both effective and personalized to enhance adherence and long-term engagement. So far, it has been unclear if exercising during concentrated time over two days per week, for example, on weekends ("weekend warrior" style) is as effective as spreading it throughout the week.

The study from the Global NASH/MASH Council (GNC) published in Liver International found that both weekend warriors and regularly active individuals had lower rates of MASLD, lower risk of heart disease, and lower mortality than those who were inactive. These results suggest that even concentrated bursts of exercise can provide major health benefits for people with MASLD.