Large Database Analysis

The COR-LD data analytics team has extensive expertise in the acquisition, management, and analysis of large-scale epidemiologic, clinical, and administrative datasets. The team has been a leader in leveraging both publicly available and proprietary data sources to advance the understanding of liver disease epidemiology, clinical outcomes, and healthcare utilization.

COR-LD investigators have conducted landmark analyses using major national and international databases, including the National Health and Nutrition Examination Survey (NHANES), U.S. Medicare claims, the National Inpatient Sample (NIS), the Surveillance, Epidemiology, and End Results (SEER) program, the Medical Expenditure Panel Survey (MEPS), the Scientific Registry of Transplant Recipients (SRTR), the UK Biobank, the Global Burden of Disease (GBD) study, and the United Nations Food and Agriculture Organization (UN FAO) databases, among others.

In addition, COR-LD maintains a large, well-characterized patient-reported outcomes (PRO) database comprising more than 10,000 patients with diverse liver diseases, with linked clinical, laboratory, and PRO data. The group has also established a Global Liver Registry that has prospectively enrolled over 19,000 patients worldwide to assess clinical and patient-reported outcomes across geographic regions. Furthermore, the Global MASLD Project represents one of the largest datasets to date, including nearly 20,000 patients with biopsy-proven MASLD, with extensive clinical, laboratory, noninvasive testing (NIT), and longitudinal outcomes data.

Analyses derived from these resources have resulted in numerous high-impact publications and have made substantial contributions to the understanding of MASLD and other liver diseases, helping to inform clinical practice, research priorities, and health policy.